Поликватерниум 1

Description

Polyquaternium 1 (INCI Polyquaternium-1), also known as polydronium chloride, Polyquad, Onamer M, is a polymer quaternary ammonium salt. The chain is built from alternating dimethyliminium and butene-1,4-diyl fragments, the terminal groups contain tris(2-hydroxyethyl)ammonium residues, and the counterion is chloride. The main practical difference from low-molecular quaternary ammonium antiseptics is that the molecule is large and therefore does not penetrate well through the membranes of corneal epithelial cells. This explains its use as a preservative for ophthalmic formulations with less irritating effects compared to benzalkonium chloride.

Basic Attributes

• CAS No.: 75345-27-6
• Chemical formula: (C6H12N)nC16H36N2O6.3Cl
• Molecular weight: 810.21
• Exact weight: 555.261
• PSA Specifications: 121
• XLogP3: 0.00000

Properties

• Class: cationic polymer, quaternary ammonium salt
• Solubility: soluble in water
• Charge: constant positive, does not depend on the pH of the environment
• Action: bacteriostatic, inhibits the growth of microbial contaminants

Scope of application

• preservative for multi-dose eye drops and preparations for topical use in ophthalmology
• preservative for solutions for storing and processing contact lenses
• component of eye care products, where it additionally works as a thickener, improving the stability and transparency of the composition

Mechanism of action

The polymeric polycation is adsorbed on the negatively charged surface of the bacterial cell and disrupts the functions of its membrane, causing the growth of microorganisms to stop. The large size of the macromolecule limits its penetration into the cells of the corneal epithelium, therefore the irritating effect on the eye is less pronounced than that of monomeric quaternary ammonium antiseptics. When developing ophthalmic forms, the interaction of the polymer with eye cells is still assessed separately.

Safety Information

• Hazard Statements: H400 - Very toxic to aquatic life
• Precautionary Statements: P273, P391, P501

Storage and handling

Keep in a closed container. Do not dispose of solutions and residues into sewers or water bodies - the product is acutely toxic to aquatic organisms. Collect spills under P391, transfer waste to a licensed operator under P501. When working with concentrates, use gloves and safety glasses.