Тенациссозид I

Description

Tenacissoside I is a C21-steroidal (polyoxypregnane) glycoside isolated from the Marsdenia tenacissima plant. The second name in the catalogs is tenacissimoside B. The aglycone belongs to the tenacigenin B series: a pregnane skeleton with an 8.14 epoxy bridge, an acetyl group at C-12 and a benzoyl group at C-11. A disaccharide chain of 2,6-dideoxy sugars methylated at hydroxyls is attached to the C-3 position. The full systematic name is given in the synonyms of the card.

Basic Attributes

• CAS No.: 191729-44-9
• Chemical formula: C44H62O14
• Molecular Weight: 815.0
• Exact weight: 814.413940
• PSA Specifications: 178.04000
• XLogP3: 5.34

Physico-chemical characteristics

• Density: 1.3
• Boiling point: 850.8 ± 65.0 °C at 760 mm Hg. Art.
• Flash point: 247.2 ± 27.8 °C
• Refractive index: 1.580

The last three indicators and density were obtained by calculation based on the structure of the molecule, as indicated by uncertainty intervals; For a thermally unstable glycoside, the boiling point has no experimental meaning.

Origin and role in raw materials

Marsdenia tenacissima is a medicinal plant, from the roots and stems of which more than forty C21-steroid glycosides have been isolated. This group of compounds is considered the main active fraction of the raw material: glycosides are built from a steroid aglycone and a chain of 2-deoxy sugars up to six units long. Tenacissoside I is one of the components for which pharmacokinetic studies are being conducted: methods for its determination in the blood plasma of rats have been developed using UHPLC with tandem mass spectrometry together with tenacissosides G and H.

Scope of application

• analytical standard for monitoring the authenticity and quality of Marsdenia tenacissima raw materials and preparations based on it
• reference substance in UHPLC-MS/MS and HPLC methods
• object of preclinical studies of pharmacokinetics and metabolism of C21-steroid glycosides
• reagent for studying structural-functional relationships in the series of polyoxypregnane glycosides

Storage and handling

The product is for research purposes and is not intended for use in humans and animals outside of scientific protocols. Store in a tightly closed container, protected from light at a low temperature according to the batch passport; ester groups at C-11 and C-12 are sensitive to hydrolysis in an alkaline environment. Wear gloves and safety glasses and weigh without dust. The product card does not contain transport codes or GHS classifications.