Ятейн

Description

Yatein, a lignan of the dibenzylbutyrolactone series. Stereochemistry (3R,4R). The molecule combines a methylenedioxyphenyl fragment and a trimethoxybenzyl substituent on the lactone ring. The compound is isolated from plant materials, in particular from the leaves of the cypress tree (Chamaecyparis obtusa), as well as from Austrocedrus chilensis and Calocedrus formosana. In biosynthesis, yatein acts as a precursor to podophyllotoxin.

Basic Attributes

• CAS No.: 40456-50-6
• Chemical Formula: C22H24O7
• Molecular Weight: 400.42176
• Exact weight: 400.42
• DSSTox ID: DTXSID50193471
• PSA Specifications: 72.45
• XLogP3: 3.06

Physico-chemical characteristics

• Density: 1.3 plus or minus 0.1 g/cm³
• Boiling point: 564.9 plus or minus 45.0 °C at 760 mm Hg. Art.
• Flash point: 246.2 plus or minus 28.8 °C
• Refractive index: 1.577

Scope of application

• reference standard for the analysis of lignans in plant materials and extracts
• reagent for pharmacological and biochemical research
• object of work on podophyllotoxin biosynthesis

The substance is intended for scientific and analytical work; it is not supplied for human use.

Activity being studied

Data have been published on suppression of the reproduction of herpes simplex virus type 1 in HeLa cells without pronounced cytotoxicity; the mechanism is associated with inhibition of the expression of viral alpha genes, including ICP0 and ICP4, stopping the synthesis of viral DNA and the formation of structural proteins. Based on the structural similarity to podophyllotoxin, the possibility of common cytoplasmic targets, primarily microtubules, is discussed, with which antiproliferative effects are associated.

Storage and transportation conditions

Store in a tightly closed container, in the dark, away from moisture. Transport sealed, protected from heat and direct sunlight.