Тоддалозин

Description

Toddalosin is a natural biscoumarin, that is, a dimeric molecule built from two coumarin fragments. Isolated from the root bark of Toddalia asiatica, a tree-like vine of the Rutaceae family, a traditional medicinal plant of South and Southeast Asia and East Africa. The product is supplied as an isolated natural compound for research and analytical applications.

Basic Attributes

• CAS No: 137182-37-7
• Chemical formula: C32H34O9
• Molecular weight: 562.6
• Exact weight: 562.22028266

Physico-chemical characteristics

• Density: 1 ± 0.06 g/cm3 (predicted value)
• Boiling point: 752.5 ± 60.0 °C (predicted value)

Both values ​​were obtained by calculation and not by measurement, and are given for guidance when selecting isolation and storage conditions.

Origin and class of compound

Toddalia asiatica coumarins have been studied in sufficient detail: a number of compounds of this series have been isolated from the roots and root bark of the plant, including simple coumarins, prenylated derivatives and dimeric structures, which include toddalosin. The molecular formula C32H34O9 and mass 562.6 correspond to a dimer with several oxygen-containing substituents.

Scope of application

• reference standard for phytochemical analysis of Toddalia asiatica extracts by HPLC and mass spectrometry
• subject of natural compound chemistry research: coumarins from this plant have been evaluated, in particular, for acetylcholinesterase inhibition and neuroprotective properties in models of oxidative stress and beta-amyloid cell damage
• starting material for obtaining derivatives in works on structural-functional relationships

Storage and handling

Like other isolated coumarins, the product is stored in a tightly closed container, in the dark, at a low temperature, protected from moisture and atmospheric oxygen: the coumarin core and phenolic substituents are sensitive to light and oxidation. Work is carried out with gloves, weighing is carried out under a hood.