Метилофиопогонанон А

Description

Methylophiopogonone A is a homoisoflavonoid from the roots of Ophiopogon japonicus, the raw material of Radix Ophiopogonis. The main representative of this group in the plant. B differs from methylophiopogonanone in the substituent at C-3: instead of the 4-methoxybenzyl group there is a 1,3-benzodioxol-5-ylmethyl, that is, a methylenedioxyphenyl fragment. The rest of the skeleton is the same: 2,3-dihydrochromon-4-one with hydroxyls at C-5 and C-7 and methyl groups at C-6 and C-8, configuration (3R).

Basic Attributes

• CAS No: 74805-92-8
• Chemical formula: C19H18O6
• Molecular Weight: 342.345
• Exact weight: 342.34
• PSA specifications: 85.22000
• XLogP3: 5.16

Physico-chemical characteristics

• Density: 1.4 ± 0.1 g/cm3
• Boiling point: 580.1 ± 50.0 °C at 760 mm Hg. Art.
• Flash point: 212.9 ± 23.6 °C
• Refractive index: 1.654

Biological activity according to literature

• Reducing the severity of hyperlipidemia caused by a high-fat diet (mechanistic model studies)
• weakening of cardiomyocyte apoptosis
• reduction of damage during cerebral ischemia and reperfusion
• antioxidant activity among ophiopogon homoisoflavonoids

Scope of application

• marker compound and analytical standard for monitoring Radix Ophiopogonis raw materials using HPLC with diode array detection and LC-MS/MS
• reference substance for the identification of homoisoflavonoids
• research substance in work on lipid metabolism and myocardial protection

Safety Information

The original card does not contain transport codes, labels, hazard instructions or precautions. Handle in accordance with the general rules for working with reagents: gloves, safety glasses, in a fume hood. For the related methylophiopogonanone B, the card states H317 - risk of allergic skin reaction, so it is reasonable to exclude direct skin contact here as well.

Storage and transportation conditions

The container is tightly closed, the room is dry, dark, the temperature is low. Phenolic hydroxyls at C-5 and C-7 are oxidized by atmospheric oxygen, the methylenedioxy group is sensitive to strong acids, so the product is kept in a neutral environment without access to light.