Пахиаксимин А

Description

Pachyaximin A is a steroidal alkaloid of the pregnane series, isolated from the Pachysandra axillaris plant of the boxwood family (Buxaceae). The compound combines the characteristics of a steroid and an alkaloid: the tetracyclic pregnane framework bears a dimethylamino group at C20 and a methoxyl group at C3. The systematic notation is (3β,20S)-3-methoxy-N,N-dimethylpregn-5-en-20-amine.

Basic Attributes

• CAS No: 128255-08-3
• Chemical formula: C24H41NO
• Molecular Weight: 359.58844
• Exact weight: 359.318817

Characteristics

• PSA: 12.5
• XLogP3: 6.28
• Density: 1.0 ± 0.1 g/cm³
• Boiling point: 430.1 ± 28.0 °C at 760 mm Hg. Art.
• Flash point: 126.0 ± 26.3 °C
• Refractive index: 1.529

The combination of XLogP3 6.28 and PSA 12.5 describes a clearly lipophilic molecule with a minimum of polar groups: the substance is practically insoluble in water, and it is convenient to work with it in organic solvents.

Biological activity

Pachyaximin A has demonstrated antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyogenes.

Plant source

Pachysandra axillaris is a plant used in folk medicine and is rich in pregnane alkaloid derivatives. A number of related compounds have been isolated from it; pachyaximin A is one of the most studied representatives of this group.

Applications

• standard sample for analyzing the alkaloid composition of Pachysandra raw materials
• reagent in microbiological studies of the activity of steroid alkaloids
• starting compound for structural-functional work on pregnane alkaloids

Synonyms

Pachyaximin A; Pregn-5-en-20-amine, 3-methoxy-N,N-dimethyl-, (3b,20S)- (9CI). Catalog section - alkaloids.

Storage and handling

Store refrigerated, in a tightly closed container, away from light. As a base, the alkaloid is capable of absorbing carbon dioxide from the air - keep the container closed. Work with the hitch with gloves, under a hood.