Гаплопин

Description

Haplopin is a furoquinoline alkaloid, 4,8-dimethoxyfuro[2,3-b]quinolin-7-ol. Isolated from plants of the genus Haplophyllum (H. bucharicum, H. dauricum) and other representatives of the rue family; also known as 7-hydroxy-8-methoxydictamnin. Together with skimmianin and γ-fagarin, it constitutes the three main furoquinolines of these plants. A distinctive feature of the class is its photoactivated biological activity: like psoralens, haplopin binds to DNA upon irradiation and under these conditions exhibits an antimicrobial effect against Staphylococcus aureus. According to some data, the substance suppresses melanogenesis without pronounced cytotoxicity.

Basic Attributes

• CAS No.: 5876-17-5
• Chemical formula: C13H11NO4
• Molecular weight: 245.234
• Exact weight: 245.23
• PSA specifications: 60.7
• XLogP3: 1.4

Physico-chemical characteristics

• Melting point: 202-204 °C

Scope of application

• phytochemical standard for the analysis of raw materials of Haplophyllum and other rutaceae
• studies of photoactivated DNA binding and photoantimicrobial action of furoquinolines
• work to suppress melanogenesis, screening of cosmetic and dermatological assets
• study of the anti-inflammatory and antioxidant properties of alkaloids of this series

Safety Information

• Hazard class code: 25 - toxic if swallowed
• Safety instructions: 45 - in case of accident or illness, consult a doctor immediately, show the label
• Tags: T (toxic)

Storage and handling

The substance is classified as toxic (label T), so weighing and dissolving should be carried out in a fume hood, wearing gloves and safety glasses, to prevent ingestion. The container is tightly closed, the room is dry, protected from light - taking into account the photoactivity of the molecule, this is essential. Store separately from food and feed. Data on density, solubility, LD50 and transport codes are not available in the original card and are not presented here.